Reference

Platelet-derived growth factor (PDGF) is a crucial regulator of several cellular functions, particularly in mesenchymal cells. Here are the primary functions regulated by PDGF:

1. Cell Growth and Division: PDGF is a potent mitogen, meaning it stimulates cell division, especially in connective tissue cells such as fibroblasts, smooth muscle cells, and glial cells.

2. Wound Healing: PDGF plays a significant role in wound healing by promoting the proliferation and migration of fibroblasts and smooth muscle cells to the site of injury, aiding in tissue repair.

3. Angiogenesis: It is involved in the formation of new blood vessels (angiogenesis), which is crucial for supplying nutrients and oxygen to healing tissues.

4. Regulation of Interstitial Fluid Pressure: PDGF helps regulate the pressure of interstitial fluid, which is important for maintaining tissue homeostasis.

5. Extracellular Matrix Production: It stimulates the production of extracellular matrix components, which provide structural support to tissues.

6. Autocrine Stimulation in Tumor Cells: PDGF can function in autocrine loops, particularly in tumor cells, promoting their growth and survival.

These functions make PDGF a critical factor in both normal physiological processes and pathological conditions, such as cancer and cardiovascular diseases.

For more detailed information, you can refer to the Wikipedia article on PDGF and other scientific resources.