Hess's research significantly advanced our understanding of acetylcholine receptors, particularly through his work on the mechanisms of neurotransmission. One of his key contributions was the identification of the ion channels associated with acetylcholine receptors, which are critical for synaptic transmission in the nervous system.

His studies demonstrated how acetylcholine binds to these receptors, leading to conformational changes that open ion channels, allowing the influx of sodium ions. This process is essential for muscle contraction and the propagation of nerve impulses. Hess's work helped clarify the pharmacological properties of acetylcholine receptors and their role in various physiological processes.

Moreover, his research laid the groundwork for the development of drugs that target these receptors, which have implications in treating conditions such as myasthenia gravis and other neuromuscular disorders.

For a deeper dive into Hess's contributions and the broader context of acetylcholine receptor research, you might explore academic journals or review articles focusing on neurobiology and pharmacology. If you need specific articles or sources, please let me know!