Subcutaneous T-cell lymphoma (STCL) is a rare type of non-Hodgkin lymphoma that primarily affects the skin. The treatment options for initial therapy can vary based on the specific subtype of T-cell lymphoma, the extent of the disease, and the patient's overall health. Here are some commonly offered treatments:

1. Topical Therapies:

   • Corticosteroids: These are often used to reduce inflammation and control symptoms.
   • Chemotherapy Creams: Agents like mechlorethamine or other topical chemotherapeutics may be applied directly to the skin lesions.

2. Systemic Chemotherapy:

   • For more extensive disease, systemic chemotherapy regimens may be employed. Common regimens include CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone) or other combinations tailored to T-cell lymphomas.

3. Radiation Therapy:

   • Localized radiation can be effective for treating specific lesions, especially if they are symptomatic or causing significant discomfort.

4. Immunotherapy:

   • Agents like monoclonal antibodies (e.g., brentuximab vedotin) may be used, particularly in cases that are more aggressive or resistant to other treatments.

5. Targeted Therapy:

   • Newer agents targeting specific pathways involved in T-cell lymphoma may be considered, depending on the molecular characteristics of the lymphoma.

6. Clinical Trials:

   • Participation in clinical trials may be an option for patients, providing access to novel therapies that are not yet widely available.

7. Supportive Care:

   • This includes managing symptoms and side effects of treatment, as well as psychological support for patients and families.

It's essential for patients to discuss their specific case with a hematologist or oncologist who specializes in lymphomas to determine the most appropriate treatment plan based on their individual circumstances.