Reference

Annexin A13 is a member of the annexin family of proteins, which are known for their calcium-dependent phospholipid-binding properties and involvement in various cellular processes, including signal transduction pathways. According to the search results, annexin A13 contributes to signal transduction pathways in several ways:

1. Regulation of Cellular Growth and Signaling: Members of the annexin family, including annexin A13, play a role in the regulation of cellular growth and signal transduction pathways GeneCards.

2. Proliferation, Migration, and Invasion: Studies have shown that ANXA13 can regulate the proliferation, migration, invasion, cell cycle, and apoptosis of certain cells, such as ccRCC cells, indicating its role in signal transduction related to these cellular activities NCBI.

3. Phospholipase Inhibition and Cytoskeletal Interactions: Annexin A13, like other annexins, is involved in phospholipase inhibition and cytoskeletal interactions, which are crucial for signal transduction Prospec Bio.

4. Regulation of Membrane Protein Transport: Annexin A13 is associated with the regulation of Golgi to plasma membrane protein transport, which is a critical aspect of cellular signaling Wikipedia.

5. Inflammation Regulation: Annexin A13 is also involved in regulating inflammation, which is closely linked to signal transduction pathways ScienceDirect.

In summary, annexin A13 contributes to signal transduction pathways through its roles in cellular growth regulation, modulation of cell behavior, phospholipase inhibition, cytoskeletal interactions, and inflammation regulation. These functions highlight the multifaceted role of annexin A13 in cellular signaling and its potential implications in various physiological and pathological conditions.