Reference

Transmissible Spongiform Encephalopathies (TSEs) are a group of rare, progressive, neurodegenerative disorders that affect humans and animals. Here are some common symptoms experienced by individuals with TSEs:

1. Cognitive and Mental Deterioration:

   • Memory loss
   • Progressive mental deterioration
   • Rapidly developing dementia
   • Confusion and disorientation

2. Behavioral and Psychiatric Symptoms:

   • Personality changes
   • Psychiatric problems such as depression
   • Anxiety and mood swings
   • Agitation and apathy

3. Motor and Coordination Issues:

   • Lack of coordination
   • Unsteady gait or walking difficulties
   • Muscle stiffness
   • Tremors and myoclonus (involuntary jerking movements)
   • Ataxia (loss of full control of bodily movements)

4. Sensory Disturbances:

   • Vision problems
   • Hearing issues
   • Sensory deterioration

5. Other Symptoms:

   • Difficulty speaking
   • Swallowing difficulties
   • Fatigue and headaches
   • Weight loss in some cases

These symptoms are indicative of brain damage caused by TSEs, leading to characteristic sponge-like changes in brain tissue. They can vary based on the specific type of TSE and typically worsen over time, ultimately leading to severe disability and death.

For more detailed information, you can refer to sources such as the National Institute of Neurological Disorders and Stroke (NINDS).

Here are some images related to TSEs:

These images illustrate the pathological changes and diagnostic imaging typically associated with TSEs.