Reference
OpenAI's Answer
Wortmannin, a known inhibitor of phosphoinositide 3-kinases (PI3K), has a significant effect on PDGF-stimulated osteoblast differentiation. When PI3K is inhibited by Wortmannin in PDGF-treated cells, there is an enhancement in osteoblast differentiation compared to cells treated with PDGF alone. This is evidenced by increased alkaline phosphatase activity and in vitro mineralization, indicating that Wortmannin can enhance the differentiation process in this context.
For more detailed information, you can refer to the study published in Science: Mechanism of Divergent Growth Factor Effects in Mesenchymal Cells.
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