Reference

Integrin-like receptors are crucial for stabilizing cell structures through their roles in cell adhesion and signaling. Here's how they assist in this process:

1. Cell-Matrix Interaction: Integrins mediate the attachment of cells to the extracellular matrix (ECM) by binding to ECM glycoproteins such as laminins, collagens, and fibronectin. This anchorage helps maintain tissue structure and cell positioning within the tissue matrix (source).

2. Bidirectional Signaling: Integrins transmit signals bidirectionally across the plasma membrane, linking extracellular ligand-binding sites with cytoplasmic domains. This enables integrins to communicate between the cell's exterior and interior, facilitating structural and mechanical support (source).

3. Cytoskeletal Linkage: By connecting to the cytoskeleton, integrins provide structural stability, influencing cell shape and mechanical properties. They play a key role in the regulation of cell movement, proliferation, and survival (source).

4. Cell-Cell and Cell-ECM Attachments: Integrins are involved in forming and stabilizing both cell-to-cell and cell-to-ECM attachments, supporting tissue architecture and cellular integrity (source).

Here are some visual representations of integrin function:

These mechanisms highlight the integral role of integrins in maintaining cellular structure and function.