Reference

The main binding functions of Annexin A13 at the molecular level include:

1. Calcium-dependent phospholipid binding: Annexin A13 binds to phospholipids in a calcium-dependent manner, which is a key function of the annexin family. This binding is crucial for various cellular processes such as membrane trafficking, repair, and vesicle aggregation UniProtKB, Wikipedia.

2. Binding to specific phospholipids: Annexin A13 is known to bind to phosphatidylserine and phosphatidylcholine. This specificity is important for its function in membrane-related processes UniProtKB, Wikipedia.

3. Direct binding to raft-like liposomes and acidic phospholipids: Myristoylation of annexin A13b enables direct binding to phosphatidylcholine, raft-like liposomes, and acidic phospholipids, which suggests a role in lipid raft dynamics and membrane organization NCBI.

4. Membrane binding and aggregation: After binding to phospholipids, annexin A13 has the ability to mediate the formation of bilayer membranes through its transverse aggregation, which is important for processes like exocytosis and apoptosis ScienceDirect.

These binding functions are essential for the role of Annexin A13 in cellular processes, and the specific molecular mechanisms are further illustrated in various research articles and protein databases.