Reference

Sodium cations (Na+) significantly impact the binding of 3H-NIS (tritiated Nisoxetine). The presence of sodium ions is crucial for the specific and total binding of 3H-NIS. Nisoxetine's binding is dependent on sodium cations, which implies that the presence of sodium enhances the binding affinity of 3H-NIS. In general, sodium ions seem to play a critical role in stabilizing the binding state or configuration necessary for efficient binding interactions with 3H-NIS. This is consistent with the general role of sodium ions in many biological binding processes where they can affect conformational states and charge interactions.

For more detailed insights, you can refer to the following source: Nisoxetine - Wikipedia.

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