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Are there any antihistamines that also function as norepinephrine reuptake inhibitors?

OpenAI's Answer

Yes, there is an antihistamine that also functions as a norepinephrine reuptake inhibitor: Chlorpheniramine. Chlorpheniramine not only serves as an antihistamine by blocking histamine receptors but also has some activity as a selective serotonin reuptake inhibitor (SSRI) with an inhibitory effect on norepinephrine neurons.

For further information, you can check out the PubMed article here.

Here are some images for a visual understanding of serotonin and norepinephrine reuptake inhibitors:

SNRI Action

Serotonin-Norepinephrine Reuptake Inhibitors

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