Reference

KIFC3 plays a crucial role in the transport of annexin XIIIb-associated membranes. It is a minus end-directed microtubule motor protein that accumulates in regions where minus ends of microtubules assemble, particularly in polarized epithelial cells. KIFC3 is localized on membrane organelles immediately beneath the apical plasma membrane of renal tubular epithelial cells and is involved in the transport of apical Triton-insoluble membranes. Overexpressing headless KIFC3 partially blocks the apical transport of annexin XIIIb, while overexpressing full-length KIFC3 accelerates it. This suggests that KIFC3 is essential for the proper transport and localization of annexin XIIIb-associated membranes to the apical region of polarized cells. The images provided further illustrate the association of KIFC3 with annexin XIIIb and its role in intracellular transport processes. For more detailed information, refer to the studies cited in the search results, such as the one published in the Journal of Cell Biology 1.