Hiram Bingham III's stance on Prohibition had a notable impact on his political career, particularly his re-election campaign. Bingham, initially elected as a U.S. Senator from Connecticut, faced significant challenges due to his position on Prohibition. He was an outspoken critic of the Prohibition laws that banned alcohol in the United States.

Bingham's support for the repeal of Prohibition was opposed by many in the Prohibition advocacy community, and this opposition contributed to his defeat in his re-election bid in 1932. According to sources, Bingham blamed Prohibition advocates for his loss (Downfall Dictionary). This indicates that his stance on this policy alienated a section of voters who supported the prohibition of alcohol and ultimately influenced the outcome of his campaign negatively.

In conclusion, Hiram Bingham III's opposition to Prohibition played a significant role in his political defeat, illustrating the deep divisions and strong sentiments surrounding Prohibition during that era.