Markers of inflammation and Vitamin E have significant effects on the peripheral nervous system function. According to various studies, inflammation is associated with accelerated decline of nerve function, and inadequate antioxidant defenses, such as Vitamin E, can contribute to this decline [1]. Vitamin E deficiency has been linked to symptoms of cerebellar dysfunction and peripheral neuropathy, which can be partially reversed by Vitamin E supplementation [2]. This suggests that maintaining adequate Vitamin E levels is crucial for the health of the peripheral nervous system.

Vitamin E, acting as an antioxidant, protects cell membranes from lipid peroxidation and preserves tissue cells from oxidative damage [3]. It also has anti-inflammatory activity and can reduce the production and release of inflammatory mediators in mast cells [4]. This anti-inflammatory effect can be beneficial for the peripheral nervous system, as inflammation can lead to harmful effects on nerves.

In conclusion, both inflammation and Vitamin E play important roles in the function of the peripheral nervous system. Inflammation can negatively impact nerve health, while Vitamin E, through its antioxidant and anti-inflammatory properties, can help protect and maintain the integrity and function of the peripheral nerves.

Inflammation and oxidative stress contribute to the pathogenesis of many diseases, including diseases of the nervous system [5].

Image Source: Antioxidants

References: [1] Markers of inflammation, vitamin E and peripheral nervous system function: the InCHIANTI study [2] Vitamin E deficiency and peripheral neuropathy [3] Review Vitamin E–gene interactions in aging and inflammatory age-related diseases [4] The Potential Role of Vitamin E and the Mechanism in the Treatment of Inflammatory Diseases [5] Lipoic Acid, Inflammation and Diseases of the Nervous System