Reference

Platelet-Derived Growth Factor (PDGF) plays a crucial role in vascularization stability. It is involved in the regulation and stabilization of blood vessels by affecting pericytes and smooth muscle cells (SMCs), which are key components for maintaining capillary stability. PDGF signaling contributes to the remodeling and stabilization of newly formed vessels, ensuring that they evolve into stable and mature structures.

PDGF functions by controlling the proliferation and migration of cells adjacent to blood vessels. For instance, PDGF is vital in angiogenesis, where it supports the maturation of blood vessels after their initial formation by vascular endothelial growth factors (VEGF). It aids in recruiting pericytes and SMCs to these nascent vessels, which helps in their stabilization and prevents regressive changes like vessel leakage or collapse.

Here are some visual representations of the PDGF signaling pathway and its role in vasculature:

For further reading, you can explore these detailed articles:

• Understanding angiogenesis and the role of PDGF
• Impact of PDGF in cardiovascular health

These sources elaborate on how PDGF stabilizes the vasculature by facilitating the interaction between different cell types essential for vessel maintenance and repair.