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What are some examples of trimethylsilylating agents?

OpenAI's Answer

Trimethylsilylating agents are commonly used in chemical synthesis, particularly in the protection of hydroxyl, amine, and carboxyl functional groups. Here are some examples of these agents:

  1. Trimethylsilyl chloride (TMSCl) - Often used to introduce trimethylsilyl groups into compounds.
  2. Bis(trimethylsilyl)acetamide (BSA) - Known for its efficiency in trimethylsilylation reactions.
  3. N,O-Bis(trimethylsilyl)trifluoroacetamide (BSTFA) - Widely used in gas chromatography due to its volatility and stability.
  4. Trimethylsilyl trifluoromethanesulfonate (TMSOTf) - A potent silylating agent used in various organic syntheses.
  5. Trimethylsilyl azide - Primarily used for the azidolysis of epoxides.
  6. N,N-Bis(trimethylsilyl)urea (BSU) - Commonly used in the trimethylsilylation of alcohols.

For a visual reference, here's an image showing some commonly used trimethylsilylating agents from ResearchGate: Trimethylsilylating agents

For further details, you can check the source at ScienceDirect and ResearchGate.

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