Reference

Positive and negative non-linear effects refer to how certain reactions or interactions deviate from an expected linear relationship. Here's a brief overview:

Positive Non-linear Effects

• Amplification: These effects can lead to outcomes that are greater than expected. For example, in asymmetric reactions, a positive non-linear effect might show a higher enantiomeric excess (ee) of a product than what would be predicted under a linear model. This phenomenon is sometimes referred to as "asymmetric amplification" (Wikipedia).
• Example: In catalytic processes, positive non-linear effects can enhance the selectivity or yield unexpectedly.

Negative Non-linear Effects

• Diminished Outcomes: These lead to results that are weaker or less than anticipated compared to linear predictions. They can indicate asymmetric depletion or dilution of reactive components.
• Example: In kinetic resolution, a negative non-linear effect might manifest where the conversion or selectivity deviates negatively from the expected model (Nature).

These effects can be critical in fields like catalysis, pharmacology, and material science, where understanding and leveraging non-linear behaviors can optimize performance and outcomes.