What biological processes is the SPSB1 protein involved in?

Reference

Complete information for SPSB1 gene (Protein Coding), SplA/Ryanodine Receptor Domain And SOCS Box Containing 1, including: function, proteins, disorders, pathways, orthologs, and expression. ... Gene Ontology (GO) - Biological Process for SPSB1 Gene. GO ID Qualified GO term Evidence PubMed IDs; GO:0006511 3 5: involved_in ubiquitin-dependent ...

www.genecards.org

To uncover the intrinsic mechanisms of iNOS regulation, we have characterized the SPRY domain- and SOCS box-containing protein 1 (SPSB1), SPSB2, and SPSB4 that interact with the N-terminal region of iNOS in a D-I-N-N-N sequence-dependent manner. ... SPSB1 and SPSB4 have greater effects on these biological processes of iNOS regulation than SPSB2 ...

www.jbc.org

As such, a better understanding of the biological processes that drive recurrent disease is essential. To address the challenges that recurrent breast cancers present, ... they found that both mRNA and protein levels of the SP RY domain-containing S OCS B ox protein 1 (SPSB1) were significantly elevated in tumors that relapsed after oncogene ...

www.ncbi.nlm.nih.gov

OpenAI's Answer

The SPSB1 protein is involved in several biological processes, including:

Ubiquitin-Dependent Processes: SPSB1 is part of pathways that involve ubiquitin-dependent mechanisms. Source
Regulation of Inducible Nitric Oxide Synthase (iNOS): SPSB1 interacts with iNOS, influencing its regulation. Source
Transforming Growth Factor-β (TGF-β) Pathway: It's a negative regulator in the TGF-β pathway, affecting cell proliferation and differentiation. Source
NF-κB Activation: SPSB1 acts as a negative regulator of the NF-κB pathway, influencing immune responses. Source
Breast Cancer Recurrence: Elevated levels of SPSB1 have been observed in recurrent breast cancer tumors. Source

Here are some relevant images depicting the involvement of SPSB1 in these processes:

SPSB1 TGF-β Regulation SPSB1 Protein Structure

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Reference

OpenAI's Answer

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