Reference

Paganelli's research on immune complexes in atopic dermatitis revealed significant findings. The research demonstrated that immune-complex levels were notably elevated in individuals with atopic dermatitis, with IgG immune complexes being significantly higher compared to control subjects. Specifically, the levels were 50 ± 10 SE μg/ml in those with eczema versus 11 ± 9 μg/ml in controls, indicating a stark difference (p < 0.0047) [1]. Furthermore, patients with atopic dermatitis were found to have 5-32% of their serum IgE present in a high molecular weight form, suggesting the presence of immune complexes with self IgE [3]. These findings underscore the role of immune complexes in the pathogenesis of atopic dermatitis and provide insights into potential diagnostic and therapeutic targets. The images provided further illustrate the complex nature of immune responses in atopic dermatitis [4][5][6][7][8][9][10][11].

References:

1. Elevated IgG immune complexes in children with atopic eczema
2. Role of immune complexes in atopic dermatitis - PubMed
3. IgG anti‐IgE in circulating immune complexes in the hyper‐IgE syndrome