Reference

Annexin A13 expression differs between humans and mice, with some key distinctions:

1. Tissue-Specific Expression: In humans, annexin A13 is predominantly expressed in the intestine, with limited expression in other tissues. In contrast, mice may exhibit different patterns of expression across various tissues, although specific details were not found in the provided search results. Source

2. Gene Structure and Function: The human annexin A13 gene has acquired intestine-specific regulatory elements that are not present in mice, suggesting a divergence in gene regulation and function between the two species. Source

3. Disease Association: In humans, annexin A13 has been associated with tumor cell invasion and is considered a potential biomarker for metastatic status in colorectal cancer. Its role in mice is less clear from the provided search results. Source

4. Expression Patterns in Cancer: Human expression data indicate a correlation between annexin A13 expression and various cancers, whereas the specific expression patterns and roles in mice were not detailed in the search results. Source

5. Phenotypic Effects: Mouse models provide insights into the functional roles of annexins, including annexin A13, but the specific phenotypic effects attributed to annexin A13 mutations in mice were not detailed in the search results. Source

In summary, annexin A13 shows tissue-specific expression patterns in humans, particularly in the intestine, and is associated with certain diseases like colorectal cancer. The expression and functional roles in mice may differ due to genetic and regulatory divergences. For a more comprehensive understanding, further research and direct experimental data comparing human and mouse annexin A13 expression are needed.