Reference

Recombinant platelet-derived growth factor (PDGF) is utilized in various medical applications due to its capabilities in enhancing tissue regeneration and healing. Here are some of the primary medical applications:

1. Periodontal and Orthopedic Bone Defects: PDGF has received FDA approval for the treatment of periodontal and orthopedic bone defects. It is used to promote regeneration of bone and supporting tissues in these areas source.

2. Dermal Wound Healing: PDGF is involved in promoting dermal wound healing by enhancing the recruitment and proliferation of cells necessary for wound repair. This makes it useful in treating various types of dermal wounds source.

3. Chronic Foot Ulcers in Diabetic Patients: Recombinant human PDGF was the first recombinant protein approved by the FDA for this condition. It helps in the treatment and healing of chronic foot ulcers, which is a common complication in diabetes (Regranex) source.

4. Oral Clinical Indications: PDGF is also being investigated for its potential in various oral clinical applications, such as enhancing the healing and regeneration of gingival tissues and bone in dental surgeries.

These applications leverage the growth factor's ability to stimulate cell proliferation and tissue regeneration effectively.