Methoxetamine (MXE) and ketamine are both dissociative anesthetics, but they have some differences in terms of effects and pharmacology:

1. Duration of Effects: Methoxetamine generally has a longer duration of effects compared to ketamine. While ketamine's effects typically last around 1-2 hours, MXE can last 3-5 hours or even longer, depending on the dose and individual metabolism.

2. Potency: Methoxetamine is often considered to be more potent than ketamine, meaning that smaller doses are required to achieve similar effects.

3. Subjective Experience: Both substances can induce dissociative states, but users often report that MXE provides a more intense and prolonged dissociative experience. MXE is sometimes described as having a more euphoric and less anesthetic effect compared to ketamine.

4. Aftereffects: Users of methoxetamine sometimes report longer-lasting aftereffects, including a sense of well-being or mild euphoria, which can persist for several hours after the main effects have worn off. Ketamine's aftereffects are typically shorter.

5. Pharmacology: Both methoxetamine and ketamine act as NMDA receptor antagonists, but methoxetamine also has additional activity at serotonin and dopamine receptors, which may contribute to its unique effects and longer duration.

6. Legal Status and Availability: Ketamine is a medically approved anesthetic and is used in clinical settings, while methoxetamine was developed as a research chemical and has no approved medical use. This affects their legal status, with methoxetamine being banned or controlled in many countries.

7. Safety and Risks: Both substances carry risks, including the potential for psychological dependence and harmful effects with excessive use. However, the longer duration and potency of methoxetamine may increase the risk of adverse effects, particularly in unregulated or recreational contexts.

It's important to note that the use of either substance outside of a medical setting carries significant risks, and their effects can vary widely between individuals.