The 1901 U.S. Open is notable for being the first time that the tournament was played at the Myopia Hunt Club in South Hamilton, Massachusetts. This event was significant not only because of its location but also because Willie Anderson won, marking the beginning of his remarkable career as a four-time U.S. Open champion. Interestingly, Anderson and Alex Smith finished with the same score of 331, which was the highest winning score in U.S. Open history at that time. This tournament set the stage for future competitions and established the U.S. Open as a premier event in the golf calendar.
For more details on the 1901 U.S. Open, you can check out the sources: Golf Compendium and Wikipedia.