Reference

The long-term immunologic effects of thymectomy in myasthenia gravis (MG) patients include mild T-cell lymphopenia and an expansion of some Vβ families among circulating CD4+ and CD8+ T cells, as indicated by multiple studies [1][2][3]. Thymectomy, a common treatment for MG, impacts the immune system, leading to these alterations in T cell subsets [4]. The removal of the thymus can affect the development of the immune system, especially if done early in life [10]. While thymectomy in juvenile MG patients is considered safe regarding long-term immunological effects [11], it is important to monitor patients for potential autoimmune flare-ups and new-onset autoimmune diseases post-thymectomy [12]. Overall, thymectomy can result in significant changes to the immune system in MG patients, necessitating careful consideration and long-term follow-up [5][6][7][8][9].