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Which specific calcium-dependent functions are associated with Annexin A13?

Moonshot's Answer

Annexin A13 is a calcium-dependent phospholipid-binding protein that plays specific roles in cellular functions. According to the search results, these functions include:

  1. Membrane Binding: Annexin A13 binds to membranes enriched in phosphatidylserine or phosphatidylglycerol in a calcium-dependent manner, which is crucial for various cellular processes UniProtKB.

  2. Regulation of Cellular Growth: Members of the annexin family, including Annexin A13, play a role in the regulation of cellular growth and signal transduction pathways GeneCards.

  3. Membrane Trafficking and Repair: Annexin proteins function as Ca2+-dependent regulators of membrane trafficking and repair, potentially modulating membrane curvature JBC.

  4. Phospholipid Binding: Annexin A13 has the ability to bind to phosphatidylserine, phosphatidylcholine, and phosphatidylglycerol, which are important for membrane structure and function Wikipedia.

  5. Calcium Ion Binding: As a member of the annexin family, Annexin A13 is involved in calcium ion binding, which is essential for its function UniProtKB.

These functions highlight the importance of Annexin A13 in cellular processes, particularly those involving membrane dynamics and calcium signaling. The images provided in the search results further illustrate the structural aspects and potential mechanisms of annexin-mediated membrane interactions.

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